The Renal dysplasia Project
The project aims to identify the gene and the genetic mutation that causes the kidney disease Renal dysplasia (RD). The concept ‘Renal dysplasia’ has recently replaced ‘Progressive Nephropathy’ (PNP) as a more accurate term for the disease.
Since the inheritance of RD is thought to be autosomal recessive, it is likely that DNA from approximately ten individuals (from one breed) with the diagnosis RD and ten healthy controls are enough for the initial genetic analysis in the search for the mutation.
dysplasia and Hereditary nehpropathy
Renal Dysplasia (renal = kidney, dysplasia = unnatural cell growth) is defined as an unnatural development of the kidney tissue. The kidney tissue (glomeruli and tubuli) might be underdeveloped (foetal) and/or miss-developed, which causes inflammation and formation of fibrous tissue. In most cases, the dog will become sick and die from renal failure between the age of 4 months and 2 years of age.
We have already started the work with the Boxers by using already collected renal tissues (paraffin embedded) and by starting the collection of blood samples (DNA) from affected dogs and their families. But we still need a larger number of cases before the initial genetic analysis can be completed.
At the same time, we are trying to collect blood samples from English cocker spaniels affected with RD. We hope that dog owners as well as veterinarians will become aware of the project and organise the collection of blood samples from dogs that might suffer from RD. In addition, it is important that kidney tissues always are sent to pathological laboratory for analysis and correct diagnosis.
If you have a dog with kidney failure that could possibly be RD: ask the veterinarian for a blood sample (4 ml EDTA-tube). Please fill in the form together with the vet and send it all to:
me via email; Katarina.Stenshamn@kv.slu.se or phone +46 18 67 14 82,
/Katarina StenshamnDownload the RD-form here!!
For suspected/affected Cocker Spaniels outside Sweden's borders, where the veterinarians require
economical compensation, for their work collecting material and bloodsamples,
funds can be applied from the "Cocker-owners for RD/FN-Research"-fund.
Röra Röd 783
S-473 96 Henån
Phone: +46 (0)304-231 07